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Tuesday, 20 September 2016

Will You please like To Predict who are persons may be to win 2016 Nobel Prizes The date and time for the announcements of the Nobel Prizes -2016 are now set

Will You please like To Predict who are persons may be to win 2016 Nobel Prizes The date and time for the announcements of the Nobel Prizes are now set.
 for Announcements of the 2016 Nobel Prizes . Please click onhttp://www.nobelprize.org/…/…/prize_announcements/index.html
PHYSIOLOGY OR MEDICINE - Monday 3 October, 11:30 a.m. at the earliest
PHYSICS - Tuesday 4 October, 11:45 a.m. at the earliest
CHEMISTRY - Wednesday 5 October, 11:45 a.m. at the earliest
PEACE - Friday 7 October, 11:00 a.m.
ECONOMIC SCIENCES - Monday 10 October, 11:45 a.m. at the earliest
LITERATURE - The date will be set later.
Times listed are local time in Sweden (CET).
http://www.nobelprize.org/mediaplayer/index.php?id=1459
Please note it also care fully that it is almost impossible to predict correct actually who will win the Nobel Prizes , because the nomination process is shrouded in darks for at least next 50 years . How ever one may just guess and comment on my predictions for 2016 Nobel prizes are like these . one may surely comment on this with proper justifications why he/she suggesting or defying my predictions


Who Deserves a Nobel Prize?

NOBEL PRIZE FOR PHYSIOLOGY OR MEDICINE
I find at present three possibilities in the following domains as possible candidates  -:
A] " For TKI, Immantinib -: Prof Dennis J salmon 2] Prof NIcholus Lydon 3] Dr Bram J Duker 4]Charris L SAwers for Imantinib use is my first choice for several years together but not yet came truth
The Imatinib, drug is a staple of cancer treatment around the world, and continues to impress with it’s high success rate in treating CML patients. According to my study, the five year survival rate for CML patients before Imatinib was 30%. The survival rate for patients on imatinib is today 89%.[ please click on article at URLhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422381/ [ titled as "Next Generation Therapy in Chronic Myeloid Leukemia" aauthors arePranab Kumar Bhattacharya,corresponding author1,2 Upasana Bhattacharya,1 Rupak Bhattacharya,3 Ritwik Bhattacharya,3 Soumyak Bhattacharya,3 Rupsa Bhattacharya,3 Dalia Mukherjee,3 Oindrila Mukherjee,4 Debasis Mukherjee,4 Debasis Roy Barman,1 Soma Das,1 Anuradha Dey,1 Ranu Roy Biswas,1 and Surajit Sarkar5
[1Department of Pathology & Hematology, Calcutta School of Tropical Medicine, C.R. Avenue, Kolkata, 73 WB India]
Additional article information for this  Article information
Next Generation Therapy in Chronic Myeloid Leukemia
Pranab Kumar Bhattacharya, Upasana Bhattacharya, [...], and Surajit Sarkar
Additional article information
TKIs Imatinib is an established first-line therapy CP of CML. Before Imatinib therapy, IFN-alpha was a treatment option for CML because it induced durable remissions in a subset of CP patients. However, because of IFN toxicity, and its limited and unpredictable efficacy, IFN-alpha was displaced by Imatinib, with its limited toxicity and marked efficacy in the treatment of most CML patients. Imatinib has limitations, but the 5-year survival rate with Imatinib is approx. 89% compared with Interferon and Cytarabin (70%). About 15–20% CML become resistant to Imatinib, and the resistance is found in association with a BCR/ABL mutation T315I or with G250E mutations. Treatment of Imatinib-resistance CML is thus a challenge in clinical hematology. In addition, clinical evaluation of Imatinib has shown adverse effects, such as fatigue, severe nausea, vomiting, oedema, fluid retention, muscle cramps, muscular skeletal pain, and cutaneous disorders. With the prolonged survival time in CML, which with Imatinib is a median 40 months, BCC, SCC, melanoma (30% cases), breast cancer (the authors have found 1 case), prostate cancer (1 case), GI cancer, GU bladder cancer including RCC, a few pancreatic and cholangiocarcinomas, and metastatic carcinoma of unknown origin have also been reported in various literature [1]. These investigators concluded that increased rates of cancers were found at a large range of sites and there was immune deficiency, regardless of the mechanism of deficiency. There have also been scattered reports of co-existence of CML with other lymphoid malignancies such as CLL and multiple myeloma [1, 2]. It has also been shown that heart failure occurs in 1 in 1,000 patients receiving Imatinib, and that it also alters bone metabolism. Imatinib costs more than the Interferon + Cytarabin combination. The effects of Imatinib (as well as other kinase inhibitors) on leukemic stem or initiating cells are limited, and so it has been advisable to take a low dose of Imatinib over a long period.
Now, the second generation TKIs, such as Dasatinib and Nilotinib, have appeared. A unique spectrum of adverse events has occurred and been reported for both these TKIs [3, 4]. For Dasatinib-treated patients, the occurrence of pleural effusion has been a clinical challenge, especially when pleural effusion becomes recurrent or is accompanied by pericardial effusion, pulmonary hypertension, or an infection. Also, potential risk factors such as a pre-existing cardiac disease, arterial hypertension, or auto-immune disorders have been described for these TKIs. Several non-hematologic adverse events have been described for Dasatinib, including diarrhea, skin rash, bleeding, viral re-activation, and sometimes also many opportunistic infections, which have been reported in patients receiving Dasatinib at a dose of 270 mg daily. Nilotinib-treated patients have developed increases in pancreatic enzymes, bilirubin, and fasting glucose levels. Other non-hematologic adverse events of Nilotinib include diarrhea, folliculitis-like skin rash, and bleeding. There are a few reports of severe peripheral arterial occlusive disease (PAOD) and other vascular occlusive events (infarction) in patients receiving Nilotinib [3, 4]. Several of these patients developed a rapidly progressive and highly resistant form of PAOD after switching from Imatinib to Nilotinib [3, 4]. The question is whether patients, who had a complete molecular response (CMR or MCyR) to Imatinib or Imatinib in combination with Interferon, could safely stop drug treatment? What should be done with relapses? Do TKIs act then? SCT is still the treatment for CML that is considered to be curative in patients with AP or blast-crisis CML. Other choices which are still in clinical trial include a vaccine called CMLVAX100 which is given along with Imatinib to see if there is an increase in its effectiveness. Research into this and other cancer vaccines is continuing. The oral agent AP24534 also appears to have some activity independent of Bcr-Abl mutation. Cortes and colleagues [5] conducted a trial of AP24534 in patients with refractory CML and other hematologic malignancies. This agent inhibits survival of cell lines expressing Bcr-Abl variants at an inhibitory concentration of less than 40 nM. It also inhibits Flt-3 and c-Src. And this agent has the advantage of being orally administered
Indian J Hematol Blood Transfus. 2012 Sep; 28(3): 189–190.
Published online 2012 Apr 8. doi: 10.1007/s12288-011-0139-2
PMCID: PMC3422381 This drug has also been found useful in certain gastrointestinal cancers like GIST Lung cancer and is currently being studied as a treatment for stroke and diabetes.
B ]  My second choice May be For CRISPR -: Emmanuelle Charpentier and Jennifer A. Doudna according myself they may be  potential candidates for Medicine /or chemistry winners for developing a method to edit genes known as CRISPR/. The technique holds potential to cure deadly genetic diseases including cancers by increase apoptosis.

C] Alexander Y. Rudensky, Shimon Sakaguchi, and Ethan M. Shevach my third choice for in medicine for discovering how immune cells called regulatory T cells(Treg ) and a protein called Foxp3 works together
For physics Prize -:
,. My long years Predictions [after i was correct on  professor peter higgs for Higg's particle and quantum teleportation] were and still it is prof. Alan Guth (b. 1947). In 1979 or a little back, Prof Alan Guth developed the theory that finally became known as “cosmic inflation theory of Big Bang  and he first published his work in 1981 in journal Physics review and next in journal Nature. Cosmic inflation is the idea that at a very early time (approximately 10-36 s. after the Big Bang) the universe passed through a phase of exponentially rapid expansion. Alun Guth hypothesized that this expansion was driven by a positive vacuum energy density (negative vacuum pressure). In 2006, an orbiting telescope—the Wilkinson Microwave Anisotropy Probe (WMAP)—provided observational evidence corroborating the cosmic inflation hypothesis though the Nature of WIMP not clear before physicist.
Alain Aspect (b. 1947) for his hypothesis on correctness of Bell’s Theorem, stating that either the realism condition or the locality condition on elementary particles must fail. His Hypothesis that a light source can be split into two beams, which are then if passed through polarisers with randomized settings. When the polarities of the two beams were subsequently measured, they were found to be statistically correlated. This finding has been interpreted to mean that the locality condition is indeed violated (quantum non-locality is real). Today, Aspect is a Research Director at the prestigious National Center for Scientific Research (CNRS), in Paris.
My fourth choice is that I may probably like to see that the prize may go to the entire LIGO collaboration, considering that there were thousands of scientist involved in demonstrating Einstein’s predictions. or for the Graviton particle as gravity as a particle instead a force. But I do also understand that the Nobel committee (Royal Swedish academy of Science) will prefer to award it to maximum three individuals, and there are 3 who are kind obvious. However 2016 might be rather too early for this Nobel award, considering the nominations were due by Feb 1,2016 but probably someone knew the gravitational waves discovery was imminent and nominated them much later .yet or  to   P. A. R. Ade, K.W. Yoon,C. L. Wong, and /or as a team  for  BICEP2 or Detection of B-Mode Polarization at Degree Angular Scales by BICEP2 experiment  for  first gravitational wave published in PHYSICAL REVIEW LETTERS  PRL 112, 241101 (2014)20 JUNE 2014 
Nobel prize in Literature-:
Since 1901, the Nobel Prize in Literature has been awarded annually to an author only from any country written in any languages who has, in the words from the will of Alfred Nobel, produced "in the field of literature the most outstanding work in an ideal direction". Though individual works are sometimes cited as being particularly noteworthy, here "Work" refers to an author's work as a whole. The Swedish Academy decides who, if anyone will receive the prize in any given year. The academy announces the name of the chosen laureate in early October. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895; the others are the Nobel Peace Prize, Nobel Prize in Chemistry, Nobel Prize in Physics, and Nobel Prize in Physiology or Medicine.http://nobelprize.org/nobel_prizes/literature/nomination/. Selection of Nobel Laureates
The Swedish Academy http://www.svenskaakademien.se/en is responsible for the selection of the Nobel Laureates in Literature, and has 18 members. The Swedish Academy was founded in 1786 by Swedish King Gustav III. The Academy is composed of 18 members whose tenure is for life long. Known as "De Aderton" (The Eighteen), current members of the Academy include distinguished Swedish writers, linguists, literary scholars, historians and a prominent jurist. The Nobel Committee for Literature is the working body that evaluates the nominations and presents its recommendations to the Swedish Academy, and comprises four to five members.
Who is eligible for the Nobel Prize in Literature?
The candidates eligible for the Literature Prize are those nominated by qualified persons (see below) who have received an invitation from the Nobel Committee to submit names for consideration. Other persons who are qualified to nominate but have not received invitations may also submit nominations. No one can nominate himself or herself . In months September – Academy members confer. Having read the work of the final candidates, members of the Academy discuss the merits of the different candidates' contributionsThe Nobel Committee for Literature 2016 Members are Per Wästberg (Chairman) FD, Writer Kjell Espmark FD, Emeritus Professor, Writer Anders Olsson Professor, Writer Kristina Lugn Writer Horace Engdahl
Professor, Writer Associate Members Sara Danius Professor, Writer Katarina Frostenson
Writer https://www.nobelprize.org/…/l…/prize_awarder/committee.html
the Nobel Prize for Literature could conceivably go to anyone and the Nobel Committee often gives the award to writers who are rather relative unknowns in the national or international community based on what is known as odds ratio? Several odds are there. one such Prominent are Ladbrokes’s odds which are probably based on betting actions for winning the prize, but not the reality one The more people in a given place bets on a particular writer for winning the Nobel Prize , the shorter becomes the odds. The shorter the odds, just because a writer is a favorite of the weirdos who spend their hard-earned money betting on cultural prizes and of course obvious that odds doesn’t mean that that same writer is a favorite for the Nobel Swedish Academy always. According me based on odds
one of such is Japanese novelist and spaghetti-enthusiast Haruki Murakami ( his odds in japan 5/1 to 6/1 to highest odd in US 500/1), He's /was for last few years together probably one of the most decorated possible candidates having won nearly every major literary prize in Japan, the Jerusalem Prize, the Franz Kafka Prize, the International Catalunya Prize, the Welt-Literaturpreis, World Fantasy Award, and the Hans Christian Andersen Literature Award but not the Pulitzer award yet . So what ? He has honorary Doctorates of Letters from Yale, Princeton, Tufts, Hawaii. He's politically outspoken in both his works and in person and as of late has taken to criticizing Japan's nuclear programs and their ongoing disputes with China over the Senkaku islands.
Another such candidate may be American writers Joyce Carol Oates (highest odd from 8/1 in ER to 1600/1 US and or Mr Philip Roth currently all have 8/1 to 10/1 odds to maximum 1/800 may be favourite to committee . Bt my favorite is Milan Kundera since 2019 and he has highest odd 50/1in ER US lowest odd. Kundera was born in Brno, in what was then Czechoslovakia and is now the Czech Republic. He studied BA in literature at the Charles University in Prague, but switched to film studies. After graduation, he taught at the Institute for Advanced Cinematographic Studies. Kundera joined the Communist Party in 1948, but was expelled in 1950 for “anti-party activities”—an incident which formed the basis for his first novel, The Joke, published in Paris in 1967 (I read it .) He was readmitted to the Communist party in 1956, and expelled again in 1970. In 1975, he went into exile in France. In 2008, he was accused by French govt of having worked for the Communist secret police—a charge he vehemently denies. Three remarkable early novels—The Joke, The Farewell Waltz (1972), and Life Is Elsewhere(1973), together with a book of short stories (Laughable Loves[1969])—established Kundera as a distinctive, tragicomic voice at the intersection of the existentialist novel and the theater of the absurd. However, it was The Immortality(the book impressed me) , Book of Laughter and Forgetting (1978) and The Unbearable Lightness of Being (1984) that catapulted him onto the international stage. In these books, the author inserts his characters—with their typical human obsessions concerning aldurism extramarital love pleasure vigorous sex, death, politics all mixed and the philosophy meaning of life—into the high drama of recent Czech history. In addition to his nine novels (the last four of which were composed directly in French), Kundera has written verse, plays, and several volumes of literary sexual and philosophical reflection. Illuminating both his fiction and his essays is a vision of the novel as the best means of revealing the many-sided truth about the human predicament.
For Peace Prize -:
Thousands of people are eligible to submit nominations for the Peace Prize. The Norwegian Nobel committee typically receives as more than 200 nominations, according to the Associated Press.
 If one goes through excerpt from the will of Alfred Nobel for peace prize[ urlhttp://www.nobelprize.org/alfred_nobel/will/ ] it is said"---- one part to the person who shall have done the most or the best work for fraternity between Nations of standing armies or for holding and promotion of peace Congress The prizes for physics and chemistry shall be awarded by the Swedish Academy of Sciences; that for physiology or medical works by the Karolinska Institute in Stockholm; that for literature by the Academy in Stockholm, and that for champions of peace by a committee of five persons to be elected by the Norwegian Sorting. ". So far to my knowledge 96 peace Nobel prize awarded since 1901-2015 and amongst 103 individuals awarded Nobel peace prize , of which 65 awarded to single one Laureate ;02 prize shared among three person; 26 organization were given It was not awarded on 19 occasions: as in 1914-1916, 1918, 1923, 1924, 1928, 1932, 1939-1943, 1948, 1955-1956, 1966-1967 and 1972. Three persons were nominated several occasions but evaluation came as no.They were 1) Joseph Stalin in 1945;1947; 1948 2) Mahatma Gandhi for 1937;1938;1939;1948.he is however called missing NL 3) Adlof Hitler was nominated in 1939 [http://www.nobelprize.org/nobel.../facts/peace/index.html ] .Leo Tolstoy; EMRemorque!; Pablo Casals and Nicholas Roerich were also nominated several occasions but not awarded who really deserved peace prize. From India many personal were nominated ( from 1901- 1964 total valid nominated for which expert committee evaluated their candidature)of which Jawharlal Nehru was nominated on several occasions (1950; 1957; 1953;1954;1955;1960;1961)but denied. Other Indians nominated were from Bengal Hari mohon banerjee ( 1934;1936;1937;1939 1941) ; sri Arobindo (1950 ); Sanjib chaudhury Bengal Rau;Raja manikan .Sarbapalli Radhakrisnan was nominated in following years (1951;1953;1956; 1957; 1958;1959;1960;1961;1963;1964) besides them vinoba Bhave was also nominated sevetal occasions.Maria Montessori who fought for children education and her educational methods still followed by many English median schools of india was nominated several occasions but denied https://www.facebook.com/nobelprize/photos/a.164901829102.119895.81239734102/10153912234954103/?type=3&theater] 

  This year my choice For Peace Nobel  Prize

 References  1] : "Who Deserves a Nobel Prize? Post your message". Nobelprize.org. Nobel Media AB 2014. Web. 1 Oct 2016. <http://www.nobelprize.org/nobel_prizes/who-deserves.html?pageNum_GetGreetings=2&totalRows_GetGreetings=399



For the relativistic formula for the kinetic energy, ordinary subatomic particles are confined in an infinite well of velocity of Light [c]. So it may be however considered that Faster than Light Particle (FTL) speed phenomenon may exist in this Universe. On the other hand to day even physicists and...
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